BsAb Intelligence · Research Tools · Discovery Services

Understand the Pair. Build the Experiment.

Intelligence, research tools and discovery services for bispecific antibody development.

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PD-1 · PD-L1 · VEGF-A · DLL3 · CD3 · EGFR · LGR5 · MET · Dual Binding · SPR · BLI · TCE · BsAb · PD-1 · PD-L1 · VEGF-A · DLL3 · CD3 · EGFR · LGR5 · MET · Dual Binding · SPR · BLI · TCE · BsAb ·

Golden Target Pairs

5 pairs · 8 core targets · Grade A/B evidence

01Checkpoint × Angiogenesis

PD-1 × VEGF-A

Combines PD-1 checkpoint blockade with VEGF-A anti-angiogenesis in one molecule; flagship pair with ivonescima…

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02Checkpoint × Angiogenesis

PD-L1 × VEGF-A

Axis clinically validated (atezolizumab+bevacizumab FDA-approved 1L HCC 2020) but no PD-L1×VEGF bispecific app…

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03Tumor Target × T-cell Engager

DLL3 × CD3

The reference T-cell engager pair: DLL3 is a tumor-selective Notch ligand enriched in SCLC/neuroendocrine tumo…

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04Dual Tumor Target

EGFR × LGR5

Emerging pair combining EGFR (mature, validated) with LGR5 (Wnt/stemness, tumor-initiating cell marker) to tar…

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05Dual Receptor Targeting

EGFR × MET

Mature dual-receptor pair with an approved reference asset: amivantamab (EGFR×MET, 4 FDA NSCLC indication bull…

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Technical Notes

Resources · evergreen content

01CD155 与 DNAM-1 交叉竞争：为什么你的 TIGIT 筛选必须加这个对照Technical Notes
02Experimental Design: CD16a 158V vs 158F Side-by-Side ComparisonTechnical Notes
03How to Select the Right CD16a (FcγRIIIa) Variant for FcγR Binding StudiesTechnical Notes
04CD47 / SIRPα Blocking Assay Design: Avoiding the Pitfalls That Invalidate Your DataTechnical Notes
05Choosing CD3 Protein Formats for T-Cell Engager DevelopmentTechnical Notes
06CHO vs HEK293 for Early BsAb ExpressionTechnical Notes
07How to Design a DLL3 × CD3 Functional Screening WorkflowTechnical Notes
08How to Validate Dual Binding for a Bispecific AntibodyTechnical Notes
09Human vs Cynomolgus Antigen SelectionTechnical Notes
10How to Design an FcRn SPR Assay for pH-Dependent Antibody Half-Life EvaluationTechnical Notes
11Step-by-Step: FcRn SPR Protocol with pH 6.0 / 7.4 Dual-Buffer SwitchTechnical Notes
12FcRn 半衰期工程的突变策略：YTE、LS 与 N434A 怎么选Technical Notes
13IL-15 for NK Cell Expansion: Concentrations, Combinations, and Common FailuresTechnical Notes
14IL-15 vs IL-15/IL-15Rα Complex：什么时候复合物值得多花钱Technical Notes
15IL-21 在 NK 扩增中的角色：何时加、加多少、为什么Technical Notes
16PD-1 × VEGF-A Target Pair Landscape — What's Happening and Why It MattersTechnical Notes
17PD-L1 × VEGF-A Target Pair Landscape — Axis Validated, Format UnapprovedTechnical Notes
18DLL3 × CD3 Target Pair Landscape — The TCE Benchmark PairTechnical Notes
19EGFR × LGR5 Target Pair Landscape — An Emerging Pair With a Real Reagent GapTechnical Notes
20EGFR × MET Target Pair Landscape — Approved Reference, Multi-Generational PipelineTechnical Notes
21PD-1 / PD-L1 通路研究基础：从机制到实验设计的关键认知Technical Notes
22TIGIT / CD155 Matched Pair: Workflow and Optimization for BLI and SPRTechnical Notes

Topics

Resources · evergreen content

Protocols

Resources · evergreen content

01Protocol: CD16a SPR KD Measurement — 158V vs 158F Side by SideProtocols
02Protocol: CD47–SIRPα SPR Binding & Antibody BlockingProtocols
03Protocol: IL-15 NK Expansion (PBMC-based, Research Grade)Protocols
04Protocol: TIGIT–CD155 BLI Binding & CompetitionProtocols